Additive Beneficial Effects of Lactotripeptides Intake With Regular Exercise on Endothelium-Dependent Dilatation in Postmenopausal Women

作者:Yoshizawa Mutsuko; Maeda Seiji*; Miyaki Asako; Misono Maiko; Choi Youngju; Shimojo Nobutake; Ajisaka Ryuichi; Tanaka Hirofumi
来源:American Journal of Hypertension, 2010, 23(4): 368-372.
DOI:10.1038/ajh.2009.270

摘要

BACKGROUND
Peripheral conduit artery endothelium-dependent dilatation decreases with aging in humans. Lactotripeptides (LTPs) and regular exercise can improve endothelium-dependent dilatation, but combining these lifestyle modifications may be more effective than either treatment alone. We conducted a randomized, place-controlled trial with four different intervention arms.
METHODS
A total of 43 postmenopausal women (50-65 years old) were randomly divided into placebo, LTP, exercise and placebo (Ex+placebo), or exercise and LTP (Ex+LTP) groups. LTP or placebo administered orally for 8 weeks. The exercise groups completed an 8-week moderate aerobic exercise (walking or cycling) intervention.
RESULTS
There were no statistically significant differences in baseline flow-mediated dilatation (FMD) and most other key dependent variables among the groups. FMD significantly increased in the LTP, Ex+placebo, and Ex+LTP groups whereas no such changes were observed in the placebo control group. The magnitude of increases in FMD was significantly greater in the Ex+LTP group than other intervention groups.
CONCLUSION
We concluded that LIP ingestion combined with regular aerobic exercise improves endothelium-dependent dilatation to a greater extent than monotherapy with either intervention alone in postmenopausal women.

  • 出版日期2010-4