An enzyme-activatable probe with a self-immolative linker for rapid and sensitive alkaline phosphatase detection and cell imaging through a cascade reaction

作者：Zhang, Hongmei; Xu, Chenglong; Liu, Jie; Li, Xiaohong; Guo, Lin^*; Li, Xinming

来源：Chemical communications, 2015, 51(32): 7031-7034.

DOI：10.1039/c5cc01005e

• AGGREGATION-INDUCED EMISSION
• TURN-ON
• FLUORESCENCE PROBE
• ASSAY
• STRATEGY
• NANOPARTICLES
• HYDROLYSIS
• SUBSTRATE

We report the design and synthesis of a novel probe (1) for ALP assay by incorporating a self-immolative linker between a phosphate moiety and resorufin. Because of its good biocompatibility and rapid cell internalization, this probe also exhibited great potential for real-time monitoring of endogenous phosphatase activity in living cells.

• 出版日期2015
• 单位苏州大学