Dual Kinetically Controlled Native Chemical Ligation Using a Combination of Sulfanylproline and Sulfanylethylanilide Peptide

作者：Ding Hao; Shigenaga Akira; Sato Kohei; Morishita Ko; Otaka Akira^*

来源：Organic Letters, 2011, 13(20): 5588-5591.

DOI：10.1021/ol202316v

Dual kinetically controlled native chemical ligation using a newly developed sulfanylproline-mediated reaction in combination with an N-sulfanylethylanilide peptide was successfully applied to a previously unreported sequential coupling of peptide fragments added simultaneously to the reaction.

• 出版日期2011-10-21