Heme Oxygenase-1-Expressing Dendritic Cells Promote Foxp3(+) Regulatory T Cell Differentiation and Induce Less Severe Airway Inflammation in Murine Models

作者：Wong Tzu Hsuan; Chen Hung An; Gau Rung Jiun; Yen Jeng Hsien; Suen Jau Ling^*

来源：PLos One, 2016, 11(12): e0168919.

DOI：10.1371/journal.pone.0168919

Dendritic cells (DCs) are critical for instructing immune responses toward inflammatory or anti-inflammatory status. Heme oxygenase-1 (HO-1) is known for its cytoprotective effect against oxidative stress and inflammation, suggesting its immune regulatory role in allergic lung inflammation. HO-1 has been implicated in affecting DC maturation; however, its role in DC-mediated T-cell differentiation is unclear. In this study, we demonstrated that HO-1-expressing bone marrow-derived dendritic cells (BM-DCs) displayed tolerogenic phenotypes, including their resistance to lipopolysaccharide (LPS)-induced maturation, high level expression of IL-10, and low T-cell stimulatory activity. In addition, HO-1-expressing DCs were able to induce antigen-specific Foxp3(+) regulatory T cells (Treg) differentiation in vitro and in vivo. Also, HO-1-expressing DCs modulated the severity of lung inflammatory responses in two murine models of airway inflammation. This study provided evidence supporting the role of HO-1-expressing DCs in tolerance induction and as a potential therapeutic target for allergic asthma as well as other inflammatory diseases.

• 出版日期2016-12-29
• 单位河北医科大学