A computational model of the topographic distribution of ventilation in healthy human lungs

作者：Swan Annalisa J; Clark Alys R; Tawhai Merryn H^*

来源：Journal of Theoretical Biology, 2012, 300: 222-231.

DOI：10.1016/j.jtbi.2012.01.042

• Ventilation distribution
• Tissue deformation
• Structure-function

The topographic distribution of ventilation in the lungs is determined by the interaction of several factors, including lung shape, airway tree geometry, posture, and tissue deformation. Inter-species differences in lung structure-function and technical difficulty in obtaining high resolution imaging of the upright human lung means that it is not straightforward to experimentally determine the contribution of each of these factors to ventilation distribution. We present a mathematical model for predicting the topological distribution of inhaled air in the upright healthy human lung, based on anatomically structured model geometries and biophysical equations for model function. Gravitational deformation of the lung tissue is predicted using a continuum model. Airflow is simulated in anatomically based conducting airways coupled to geometrically simplified terminal acinar units with varying volume-dependent compliances. The predicted ventilation distribution is hence governed by local tissue density and elastic recoil pressure, airway resistance and acinar compliance. Results suggest that there is significant spatial variation in intrinsic tissue properties in the lungs. The model confirms experimental evidence that in the healthy lungs tissue compliance has a far greater effect than airway resistance on the spatial distribution of ventilation, and hence a realistic description of tissue deformation is essential in models of ventilation.

• 出版日期2012-5-7