Association of 25-hydroxyvitamin D status with obesity as well as blood glucose and lipid concentrations in children and adolescents in China

作者：Liu, Xiaojuan; Xian, Yang; Min, Min; Dai, Qingkai; Jiang, Yongmei; Fang, Dingzhi^*

来源：Clinica Chimica Acta, 2016, 455: 64-67.

DOI：10.1016/j.cca.2016.01.023

• Vitamin D
• Obesity
• Blood glucose
• Blood lipid metabolism

Background: Vitamin D is an essential micronutrient during the growth and development of the human body. Previously, most of the researches about the relationship of vitamin D and obesity were focused on adults. In this paper, the relationship between serum 25-hydroxyvitamin D [25(OH)D] and obesity among children and adolescents in China was analyzed.
Methods: From August 2012 to August 2014, 443 children and adolescents participated in this study. Serum 25(OH)D, lipid and glucose were measured in the laboratory. All the participants were classified into 2 groups (obese and non-obese group) on the basis of their BMI. They were then categorized into vitamin D deficiency, vitamin D insufficiency and vitamin D normal groups according to the serum concentrations of 25(OH)D.
Results: The concentration of serum 25(OH)D in the obese group was significantly lower than that of the non obese group (P < 0.001). The concentration of total cholesterol, low-density lipoprotein cholesterol, fasting blood glucose, fasting insulin and homeostasis model assessment for insulin resistance showed significant differences between the obese and non-obese groups (P < 0.05).
Conclusions: Children and adolescents suffering from obesity are more likely to have lower concentrations of serum 25(OH)D.

• 出版日期2016-4-1
• 单位中国人民解放军第四五二医院; 四川大学