Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp LC-6-2

作者：Wang Xiachang; Elshahawi Sherif I; Cai Wenlong; Zhang Yinan; Ponomareva Larissa V; Chen Xiabin; Copley Gregory C; Hower James C; Zhan Chang Guo; Parkin Sean; Rohr Jurgen; Van Lanen Steven G; Shaaban Khaled A^*; Thorson Jon S^*

来源：Journal of Natural Products, 2017, 80(4): 1141-1149.

DOI：10.1021/acs.jnatprod.7b00108

The structures of 12 new "enantiomeric"-like abyssomicin metabolites (abyssomicins M-X) from Streptomyces sp. LC-6-2 are reported. Of this set, the abyssomicin W (11) contains an unprecedented 8/6/6/6 tetracyclic core, while the bicyclic abyssomicin X (12) represents the first reported naturally occurring linear spirotetronate. Metabolite structures were determined based on spectroscopic data and X-ray crystallography, and Streptomyces sp. LC-6-2 genome sequencing also revealed the corresponding putative biosynthetic gene cluster.

• 出版日期2017-4