Clinical Implications from a Single-Center Study of Colorectal Adenocarcinoma in Transplant Recipients

作者：Lim Sun Min; Jung Minkyu; Shin Sang Joon; Baek Se Jin; Hur Hyuk; Min Byung Soh; Baik Seung Hyuk; Kim Nam Kyu; Ahn Joong Bae^*

来源：Oncology, 2015, 88(4): 195-200.

DOI：10.1159/000369254

• Colorectal cancer
• Organ transplantation
• Survival

Background: With the increasing burden of organ transplant recipients and improvements in allograft outcome, the incidence of neoplasms rising from these patients is an important issue.
Objective: In this study, we investigated transplant recipients with colorectal cancer to determine its incidence, clinicopathological characteristics, and prognosis.
Methods: The database of Severance Hospital was queried for all cases of colorectal adenocarcinoma among transplant recipients from August 2005 to January 2013.
Results: A total of 29 patients were diagnosed with colorectal adenocarcinoma after transplantation, and the median age at diagnosis was 58.6 years. As for primary tumor stage, 17 (58.6%) patients had stage >= 3, and distant metastasis was found in 10 (34.4%) patients. The mean time from transplantation to tumor detection was 13.7 years. The median disease-free survival was 11.0 months and the median overall survival (OS) was 18.1 months. In multivariate analysis of prognostic factors for OS, surgical resection was a positive prognostic factor (HR 1.357, p = 0.010) and the presence of distant metastasis at diagnosis was a negative prognostic factor (HR 1.047, p = 0.006).
Conclusion: The behavior of colorectal cancer in posttransplant patients is more aggressive and refractory to treatment. A separate guideline for the colorectal screening program for the posttransplant patients needs to be established.

• 出版日期2015