Application of combined test of blood, C-reactive protein, and prealbumin in the differential diagnosis of pathogens for children's upper respiratory tract infection

作者：Gan, Yanzi; Tao, Shaohua; Qi, Huan; Li, Yinfeng^*

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(1): 951-957.

• Blood test
• C-reactive protein
• prealbumin
• children
• upper respiratory infection

Upper respiratory tract infection (URI) is a common childhood disease. Accurate determination of risk factors is of great significance for the follow-up treatment. Combinations of blood test, C-reactive protein, and prealbumin in the differential diagnosis of pathogens for children's URI were investigated in this study. 538 children with URI and 40 healthy children were included in this study. Children with URI were divided into bacterial infection group, viral infection group, and other pathogens group according to the results of blood test. C-reactive protein (CRP) and prealbumin (PA) were tested for all 578 included children. Results showed that in bacterial infection group, CRP was increased (P < 0.05) and PA was decreased (P < 0.05) compared with control. In viral infection group, CRP was decreased (P < 0.05), whereas PA showed no difference to control (P > 0.05). In other pathogens group, CRP was increased (P < 0.05) and PA showed no difference to control (P > 0.05). Combination test of blood, C-reactive protein, and prealbumin improved the specificity (72.3%) and sensitivity (95.3%) on the differential diagnosis of URI. In conclusion, combined test of blood, C-reactive protein, and prealbumin can improve the diagnosis specificity and sensitivity of URI, leading to accurate determination of pathogens of URI and providing scientific foundation for follow-up treatment.

• 出版日期2017
• 单位南方医科大学