Health Status and Quality of Life in Patients with Psoriasis: An Iranian Cross-Sectional Survey

作者：Moradi Mahshid; Rencz Fanni; Brodszky Valentin^*; Moradi Ahmad; Balogh Orsolya; Gulacsi Laszlo

来源：Archives of Iranian Medicine, 2015, 18(3): 153-159.

• DLQI
• EQ-5D
• health-related quality of life
• Iran
• psoriasis

Background: Psoriasis has a significant negative impact on patients' health-related quality of life (HRQOL). This study aims to evaluate HRQOL of adult patients with psoriasis in Iran, and explore the relationship between general and disease-specific outcome measures in psoriasis.
Methods: Between May and August 2013, a Cross-sectional questionnaire survey of Consecutive outpatients was conducted at a single clinic in Shiraz, Iran. HRQOL was assessed by the general measure EuroQol 5 dimensions (EQ-5D), visual-analogue scale (EQ VAS), and the disease-specific Dermatology Life Quality Index (DLQI). Disease severity was measured by the Psoriasis Area and Severity Index (PASI).
Results: Sixty-two patients (76% males) completed the questionnaire with a mean age (SD) of 40.4 (17.5) years. Overall, 39% of the patients used only topical and 48% received systemic non-biological therapy in the past 12 Months. Median EQ-5D, EQ VAS, DLQI and PASI scores were 0.73, 60, 8 and 11.75, respectively. Out of the 62 patients, 18%, 26%, 28%, 63%, and 63% reported some or severe problem in mobility, self-care, usual activities, pain/discomfort and anxiety/depression, respectively. EQ-5D and EQ VAS correlated moderately with DLQI (r(s) = -0.44 for both, p < 0.001), but only EQ VAS correlated significantly With PASI (r(s) = -0.31, p < 0.01).
Conclusions This is the first study from Iran that assesses HRQOL in adult patients with psoriasis by EQ-5D and EQ VAS. Reduction in general HRQOL measured with EQ-5D and EQ-VAS is considerable; mostly in anxiety/depression and pain/discomfort dimensions. EQ-5D scores evaluated in this study provide country-specific data for economic evaluations.

• 出版日期2015-3