科研之友
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摘要
A novel PhI(OAc)(2)-mediated dialkoxylation of 4-aminostyrenes has been developed. A range of 2,3-disubstituted 1,4-dioxane or 1,2-dimethoxyethane derivatives were formed in 15 to 95% yields with high diastereoselectivities. This transformation was distinct from the previously reported hypervalent iodine(III)mediated dioxygenation reaction, a process via the formation of a cyclic iodonium ion intermediate. This protocol involves an oxidative dearomatization-induced nucleophilic attack and an aromatizationinduced 1,6-conjugated addition.
- 出版日期2017-11-1
- 单位复旦大学
