A Multidisciplinary Assessment of Remote Myocardial Fibrosis After Reperfused Myocardial Infarction in Swine and Patients

作者：Hervas Arantxa; Ruiz Sauri Amparo^*; Gavara Jose; Monmeneu Jose V; de Dios Elena; Rios Navarro Cesar; Perez Sole Nerea; Perez Itziar; Monleon Daniel; Morales Jose M; Minana Gema; Nunez Julio; Bonanad Clara; Diaz Ana; Vila Jose M; Chorro Francisco J; Bodi Vicente^*

来源：Journal of Cardiovascular Translational Research, 2016, 9(4): 321-333.

DOI：10.1007/s12265-016-9698-9

• Myocardial infarction
• Reperfusion
• Remote fibrosis
• Swine model

In extensive nonreperfused myocardial infarction (MI), remote fibrosis has been documented. Early reperfusion by primary angioplasty represents the gold standard method to minimize the extension of the infarction. We aimed to ascertain whether fibrosis also affects remote regions in reperfused MI in swine and patients. Swine were subjected to a transient occlusion of the left anterior descending artery followed by 1-week or 1-month reperfusion. Collagen content in the remote area macroscopically, microscopically, by magnetic resonance microimaging, and at the molecular level was similar to controls. In patients with previous MI, samples from autopsies displayed a significant increase in collagen content only in the infarct region. In patients with previous MI submitted to cardiac magnetic resonance-T1 mapping, the extracellular volume fraction in remote segments was similar to that for controls. In all scenarios, the remote region did not show a significant increase of collagen content in comparison with controls.

• 出版日期2016-8