Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment

作者：Noonan Frances P; Zaidi M Raza; Wolnicka Glubisz Agnieszka; Anver Miriam R; Bahn Jesse; Wielgus Albert; Cadet Jean; Douki Thierry; Mouret Stephane; Tucker Margaret A; Popratiloff Anastas; Merlino Glenn; De Fabo Edward C^*

来源：Nature Communications, 2012, 3(1): 884.

DOI：10.1038/ncomms1893

Malignant melanoma of the skin (CMM) is associated with ultraviolet radiation exposure, but the mechanisms and even the wavelengths responsible are unclear. Here we use a mammalian model to investigate melanoma formed in response to precise spectrally defined ultraviolet wavelengths and biologically relevant doses. We show that melanoma induction by ultraviolet A (320-400 nm) requires the presence of melanin pigment and is associated with oxidative DNA damage within melanocytes. In contrast, ultraviolet B radiation (280-320 nm) initiates melanoma in a pigment-independent manner associated with direct ultraviolet B DNA damage. Thus, we identified two ultraviolet wavelength-dependent pathways for the induction of CMM and describe an unexpected and significant role for melanin within the melanocyte in melanomagenesis.

• 出版日期2012-6
• 单位中国地震局