Anti-mycobacterial haliclonadiamine alkaloids from the Okinawan marine sponge Haliclona sp collected at Iriomote Island

作者：Abdjul Delfly B; Yagi Akiho; Yamazaki Hiroyuki^*; Kirikoshi Ryota; Takahashi Ohgi; Namikoshi Michio; Uchida Ryuji^*

来源：Phytochemistry Letters, 2018, 26: 130-133.

DOI：10.1016/j.phytol.2018.05.028

• Halichondriamine
• Haliclonadiamine
• Marine sponge Haliclona sp
• Antimycobacterial substance

Two new haliclonadiamine derivatives, halichondriamine C (1) and 1-epi-halichondriamine C (2), were isolated from the Okinawan marine sponge Haliclona sp. together with known haliclonadiamine (3) and papuamine (4). The structures of 1 and 2 were elucidated based on their spectroscopic data by comparisons with those for related compounds. Compounds 1 and 2 were epimers of each other at the C-1 position. Compounds 1 4 inhibited the growth of Mycobacterium smegmatis and M. bovis BCG and exhibited antibacterial activities against M. avium and M. intracellulare as pathogens of M. avium complex (MAC) disease.

• 出版日期2018-8