Disruption of Akt kinase activation is important for immunosuppression induced by measles virus

作者：Avota E; Avots A; Niewiesk S; Kane LP; Bommhardt U; ter Meulen V; Schneider Schaulies S^*

来源：Nature Medicine, 2001, 7(6): 725-731.

DOI：10.1038/89106

Surface-contact-mediated signaling induced by the measles virus (MV) fusion and hemagglutinin glycoproteins is necessary and sufficient to induce T-cell unresponsiveness in vitro and in vivo. To define the intracellular pathways involved, we analyzed interleukin (IL)-2R signaling in primary human T cells and in Kit-225 cells. Unlike IL-2-dependent activation of JAK/STAT pathways, activation of Akt kinase was impaired after MV contact both in vitro and in vivo. MV interference with Akt activation was important for immunosuppression, as expression of a catalytically active Akt prevented negative signaling by the MV glycoproteins. Thus, we show here that MV exploits a novel strategy to interfere with T-cell activation during immunosuppression.

• 出版日期2001-6
• 单位河北医科大学