APOE genotype and MRI markers of cerebrovascular disease Systematic review and meta-analysis

作者：Schilling Sabrina; DeStefano Anita L; Sachdev Perminder S; Choi Seung Hoan; Mather Karen A; DeCarli Charles D; Wen Wei; Hogh Peter; Raz Naftali; Au Rhoda; Beiser Alexa; Wolf Philip A; Romero Jose Rafael; Zhu Yi Cheng; Lunetta Kathryn L; Farrer Lindsay; Dufouil Carole; Kuller Lewis H; Mazoyer Bernard; Seshadri Sudha; Tzourio Christophe; Debette Stephanie^*

来源：Neurology, 2013, 81(3): 292-300.

DOI：10.1212/WNL.0b013e31829bfda4

Objective: We aimed to examine the association of APOE epsilon genotype with MRI markers of cerebrovascular disease (CVD): white matter hyperintensities, brain infarcts, and cerebral microbleeds. %26lt;br%26gt;Methods: We performed a systematic review and meta-analysis of 42 cross-sectional or longitudinal studies identified in PubMed from 1966 to June 2012 (n = 29,965). This included unpublished data from 3 population-based studies: 3C-Dijon, Framingham Heart Study, and Sydney Memory and Ageing Study. When necessary, authors were contacted to provide effect estimates for the meta-analysis. %26lt;br%26gt;Results: APOE epsilon 4 carrier status and APOE epsilon 44 genotype were associated with increasing white matter hyperintensity burden (sample size-weighted z score meta-analysis [meta]-p = 0.0034 and 0.0030) and presence of cerebral microbleeds (meta odds ratio [OR] = 1.24, 95% confidence interval [CI] [1.07, 1.43], p = 0.004, and 1.87 [1.26, 2.78], p = 0.002), especially lobar. APOE epsilon 2 carrier status was associated with increasing white matter hyperintensity load (z score meta-p = 0.00053) and risk of brain infarct (meta OR = 1.41[1.09, 1.81], p = 0.008). %26lt;br%26gt;Conclusions: APOE epsilon 4 and APOE epsilon 2 were associated with increasing burden in MRI markers for both hemorrhagic and ischemic CVD. While the association of APOE epsilon 4 with an increased burden of CVD could be partly contributing to the relationship between APOE epsilon 4 and AD, APOE epsilon 2 was associated with MRI markers of CVD in the opposite direction compared to AD.

• 出版日期2013-7-16
• 单位中国地震局