Short Report: Treatment of Suspected Hyper-Reactive Malarial Splenomegaly (HMS) in Pregnancy with Mefloquine

作者:Jaroensuk Juthamas; Stoesser Nicole; Leimanis Mara L; Jittamala Podjanee; White Nicholas J; Nosten Francois H; McGready Rose*
来源:The American Journal of Tropical Medicine and Hygiene, 2014, 90(4): 609-611.
DOI:10.4269/ajtmh.13-0706

摘要

Malaria infections in pregnancy are associated with adverse outcomes for both mother and child. There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy. This retrospective assessment reviewed the impact of mefloquine treatment on pregnant women with suspected hyper-reactive malarial splenomegaly in an area of low malaria transmission in the 1990s, showing significant reductions in spleen size and anemia and anti-malarial antibody titers without any notable negative effect on treated women or their newborns.

  • 出版日期2014-4