Acute toxicity of 30 pharmaceutically active compounds to freshwater planarians, Dugesia japonica

作者：Li Mei Hui^*

来源：Toxicological and Environmental Chemistry, 2013, 95(7): 1157-1170.

DOI：10.1080/02772248.2013.857671

• Dugesia japonica
• analgesics
• antibiotics
• beta blockers
• antihistamines

Pharmaceutically active compounds are produced worldwide and consumed in large quantities, so these chemicals are frequently detected in limnic environments posing potential ecological risks. Thirty pharmaceutically active compounds were selected for examination of their acute toxicity for freshwater planarians (Dugesia japonica). Among the 30 compounds tested, diclofenac, mefenamic acid, naproxen, propranolol HCl, and diphenhydramine HCl had a 48-h nominal LC50 below10mg L-1, and for 18 chemicals, it exceeded 100mg L-1. The 96-h nominal LC50 was below 10mg L-1 for diclofenac, mefenamic acid, naproxen, propranolol HCl, diltiazem HCl, diphenhydramine HCl, hydroxyzine HCl, and triprolidine HCl, and for 15 chemicals, it exceeded 100mg L-1. Among different therapeutic groups, analgesics were most toxic to planarians, and antibiotics were least toxic. Antihistamines and beta blockers varied in their acute toxicity to planarians. At the current environmental levels, none of the tested pharmaceutically active compounds may have acutely harmful impacts on aquatic invertebrates. To answer the question whether chronic, long-term exposure to pharmaceutically active compounds may entail ecological risks for aquatic ecosystems, further investigations with different end points in multiple species tests are needed.

• 出版日期2013-8-1