ALKALOIDS OF SIBERIA AND ALTAI FLORA. 17. SYNTHESIS OF N-CONTAINING DERIVATIVES OF THE DITERPENE ALKALOID LAPPACONITINE

作者：Romanov V E^*; Shul'ts E E; Shakirov M M; Tolstikov G A

来源：Chemistry of Natural Compounds, 2010, 46(4): 593-597.

• lappaconitine
• 5 '-bromolappaconitine
• nitration
• reduction

Nitro-derivatives of lappaconitine were synthesized for the first time by nitration of the alkaloid and its 5'-bromo-derivative using a trifluoroacetic acid and potassium nitrate nitrating mixture. Reduction of the nitro-derivatives by Sn(II) chloride in HCl produced the corresponding amino-derivatives of N-deacetyllappaconitine.

• 出版日期2010-9