Anti-inflammatory, Antioedema and Gastroprotective Activities of Aristotelia chilensis Extracts, Part 2

作者：Cespedes Carlos L^*; Alarcon Julio; Avila Jose G; El Hafidi Mohammed

来源：Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 2010, 9(6): 432-439.

• Aristotelia chilensis
• anti-inflammatory
• gastroprotective

Context: "Chilean black-berry" Aristotelia chilensis is a wild fruit that grows in Southern Chile. This fruit possesses a strong antioxidant activity and is commonly used in foods and beverages in Chile. Objective: The gastroprotective and anti-inflammatory activities of the extracts, fractions and subfractions as carrageenan- induced paw oedema in rats are reported here for the first time. Materials and methods: Extracts, fractions, subfractions and several compounds were used for measuring the effects in carrageenan- induced paw oedema inflammation of rat model and the gastroprotective activity was analyzed. Results: The results showed that extract B, fraction F-4, and ovatifolin, quercetin, myricetin, luteolin and diosmetin used as pattern compounds were the most active samples together with those subfractions rich in aglycone and phenolic compounds. Thus, SF(11)-SF(15), SF(16)-SF(20), and SF(21)-SF(25) showed the best subfractions inhibitors in similar form to indomethacin, a known selective COX inhibitor. Results demonstrated that these samples strongly inhibited the carrageenan- induced inflammation in paw of the rat oedema model. Discussion and conclusion: These findings demonstrate that the fruits and their constituents of A. chilensis are anti-inflammatory and gastroprotective and thus have great potential as nutraceuticals.

• 出版日期2010-11