Association between the Body Mass Index and the Risk of Barrett%26apos;s Esophagus in Japan

作者：Shinkai Hirohiko; Iijima Katsunori^*; Koike Tomoyuki; Abe Yasuhiko; Dairaku Naohiro; Inomata Yoshifumi; Kayaba Syoichi; Ishiyama Fumitake; Oikawa Tomoyuki; Ohyauchi Motoki; Ito Hirotaka; Asonuma Sho; Hoshi Tatsuya; Kato Katsuaki; Ohara Shuichi; Shimosegawa Tooru

来源：Digestion, 2014, 90(1): 1-9.

DOI：10.1159/000357776

• Barrett%26apos
• s esophagus
• Body mass index
• Obesity

Background: We investigated the association between long-segment Barrett%26apos;s esophagus and obesity in the Japanese population in a multicenter case-control trial. Methods: One hundred thirteen patients with endoscopically detected Barrett%26apos;s esophagus with a length of more than 2 cm and the same number of sex-and age-matched controls were prospectively enrolled. Barrett%26apos;s esophagus was diagnosed based on the Prague C and M criteria. The body mass index (BMI) of the subjects was categorized into the following groups: normal, BMI %26lt;22.9; overweight, BMI 23.0-24.9, and obese, BMI %26gt;25.0. To determine the association between BMI and the risk of Barrett%26apos;s esophagus, multi-variate logistic regression analyses were performed. Results: The basically adjusted regression model adjusted for smoking and alcohol consumption revealed that overweight and obesity were significantly associated with an elevated risk of Barrett%26apos;s esophagus (OR 2.4, 95% CI 1.2-4.7, and OR 2.5, 95% CI 1.3-4.6, respectively). The intensity of the association was not attenuated even after adjustment for gastroesophageal reflux disease-related parameters. Conclusions: An increased BMI was associated with an increased risk for Barrett%26apos;s esophagus through a gastroesophageal reflux-independent mechanism in the Japanese population. Further, unlike in Caucasian populations, being even slightly overweight with a BMI of 23.0-24.9 was an independent risk factor in the Japanese population.

• 出版日期2014