Novel Azole-Functionalited Flouroquinolone Hybrids: Design, Conventional and Microwave Irradiated Synthesis, Evaluation as Antibacterial and Antioxidant Agents

作者：Mentese Meltem; Demirbas Neslihan^*; Mermer Arif; Demirci Serpil; Demirbas Ahmet; Ayaz Faik Ahmet

来源：Letters in Drug Design and Discovery, 2018, 15(1): 46-64.

DOI：10.2174/1570180814666170823163540

• Fluoroquinolone
• 1,2,4-triazole
• 1,3,4-oxadiazole
• piperazine
• antibacterial activity
• antioxidant activity
• microwave

Background: The synthesis of new hybrid molecules consisting of several heterocyclic pharmacophores namely fluoroquinolone, 1,2,4-triazole, 1,3,4-oxadiazole and piperazine was carried out by conventional and successfully optimized microwave mediated techniques.
Methods: The structures of new compounds were confirmed using spectroscopic techniques. These compounds were screened for their antibacterial activity against E. coli, P. aeruginosa, Y. pseudotuberculosis, S. aureus, E. faecalis, B. cereus and M. smegmatis.
Results and Conclusion: Fourteen of these hybrids exhibited excellent antibacterial activities on the test microorganisms when compared with ampicillin with the mic values varying between 0.03-0.25 mu g/mL.

• 出版日期2018