Arachidonic acid diet attenuates brain A beta deposition in Tg2576 mice

作者：Hosono Takashi; Nishitsuji Kazuchika; Nakamura Toshiyuki; Jung Cha Gyun; Kontani Masanori; Tokuda Hisanori; Kawashima Hiroshi; Kiso Yoshinobu; Suzuki Toshiharu; Michikawa Makoto^*

来源：Brain Research, 2015, 1613: 92-99.

DOI：10.1016/j.brainres.2015.04.005

• Arachidonic acid
• PUPA
• Alzheimer's disease
• APP-Tg mouse
• A beta deposition

The amyloid p-protein (A beta) is believed to play a causative role in the development of Alzheimer's disease (AD). Because the amyloid precursor protein (APP), a substrate of A beta, and p-secretase and gamma-secretase complex proteins, which process APP to generate A beta, are all membrane proteins, it is possible to assume that alterations in brain lipid metabolism modulate APP and/or A beta metabolism. However, the role of polyunsaturated fatty acids in A beta metabolism remains unknown. We report here that 9 months-treatment of Tg2576 mice with arachidonic acid (ARA)-containing (ARA+) diet prevented brain A beta deposition in 17-month-old Tg2576 mice. APP processing to generate soluble APP alpha, CTF-beta, and A beta synthesis was attenuated in Tg2576 mice fed with the ARA+ diet. These findings suggest that ARA+ diet could prevent A beta deposition through the alteration of APP processing in Tg2576 mice.

• 出版日期2015-7-10