Adaptive hormetic response of pre-exposure of mouse brain with low-dose C-12(6+) ion or Co-60 gamma-ray on growth hormone (GH) and body weight induced by subsequent high-dose irradiation

作者：Zhang Hong^*; Xie Yi; Zhou Qingming; Liu Bing; Li Wenjian; Li Xiaoda; Duan Xin; Yuan Zhigang; Zhou Guangming; Min Fengling

来源：Advances in Space Research, 2006, 38(6): 1148-1151.

DOI：10.1016/j.asr.2006.03.030

• C-12(6+) heavy ion
• Co-60 gamma-ray
• low-dose pre-exposure
• mouse pituitary
• growth hormone (GH)
• adaptive hormetic response

The brain of the Kun-Ming strain mice were irradiated with 0.05 Gy of C-12(6+) ion or Co-60 gamma-ray as the pre-exposure dose, and were then irradiated with 2 Gy of 12C6+ ion or Co-60 gamma-ray as challenging irradiation dose at 4 h after per-exposure. Body weight and serum growth hormone (GH) concentration were measured at 35th day after irradiation. The results showed that irradiation of mouse brain with 2 Gy of C-12(6+) ion or Co-60 gamma-ray significantly diminished mouse body weight and level of serum GH. The relative biological effectiveness values of a 2 Gy dose of C-12(6+) ion calculated with respect to Co-60 gamma-ray were 1.47 and 1.34 for body weight and serum GH concentration, respectively. Pre-exposure with a low-dose (0.05 Gy) of C-12(6+) ion or Co-60 gamma-ray significantly alleviated reductions of mouse body weight and level of serum GH induced by a subsequent high-dose (2 Gy) irradiation. The data suggested that low-dose ionizing irradiation can induce adaptive hormetic responses to the harmful effects of pituitary by subsequent high-dose exposure.

• 出版日期2006
• 单位中国科学院近代物理研究所