Abnormalities in saccade dynamics in first-episode treatment-naive hyperthyreosis patients with no pre-existing eye damage: a primary exploratory study

作者：Sun, Yan; Kong, Xiaoming; Wang, Chen; Xu, Yongxia; Wang, Keyong; Zhu, Defa^*

来源：International Journal of Clinical and Experimental Medicine, 2016, 9(6): 11626-11632.

• Hyperthyroidism
• thyroid-associated ophthalmopathy
• visually guided saccade

Objective: To explore the potential difference of eye saccade dynamics between first-episode treatment-naive hyperthyreosis patients without pre-existing eye damage and healthy controls by using basic visually guided saccade (VGS). Methods: 15 hyperthyroidism outpatients and 15 healthy controls participated in VGS analysis. Multiple indicators, including amplitude, duration, latency, main sequence analysis was performed to evaluate the differences of peak velocity (PV) and duration between the groups and general linear model was used to find the differences on latency, peak acceleration and peak deceleration between the groups. Results: There was a statistically significant difference in V-max values between hyperthyreosis patients and healthy controls (438.47 +/- 55.46 degrees/s in control group and 486.10 +/- 51.49 degrees/s in hyperthyroidism group, Mann-Whitney U test, Z = -2.053, P = 0.040). GLM-based analysis showed that when amplitude = 10.819 degrees, PV = 311.587 degrees/s, duration = 61.94 ms, the saccade latency showed significant differences between hyperthyreosis patients (223.364 ms, 95% confidence interval (CI) = [219.245, 227.482]) and healthy controls (234.601 ms, 95% CI = [230.497, 238.705]); the peak acceleration showed significant differences between hyperthyreosis patients 14127.205 degrees/s(2) (95% CI = [14061.606, 14192.804]) and healthy controls (13959.973 degrees/s(2), 95% CI = [13894.610, 14025.337]); the peak deceleration showed no significant differences between hyperthyreosis patients (-10160.784 degrees/s(2), 95% CI = [-10263.189, -10058.378]) and healthy controls (-10194.008 degrees/s(2), 95% CI = [-10296.046, -10091.970]). Conclusion: Compared to healthy controls, hyperthyreosis patients displayed different dynamics in eye movement during VGS. Saccade tracking examination has a potential value for early detection of thyroid-associated ophthalmopathy.

• 出版日期2016
• 单位安徽医科大学; 上海市精神卫生中心