New roles for TIM family members in immune regulation

作者:Kuchroo Vijay K*; Dardalhon Valerie; Xiao Sheng; Anderson Ana C
来源:Nature Reviews Immunology, 2008, 8(8): 577-580.
DOI:10.1038/nri2366

摘要

Members of the TIM (T-cell immunoglobulin domain and mucin domain) protein family are emerging as important regulators of immune responses. As their names imply, the TIM proteins were originally thought to be T-cell-specific molecules that served mainly to regulate T-helper-cell responses. However, the recent discovery that antigen-presenting cells also express TIM molecules and the identification of new TIM-protein ligands has expanded the known roles of the TIM proteins in immune regulation.

  • 出版日期2008-8