A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils

作者：Wilson S^*; Jones F M; Fofana H K M; Landoure A; Kimani G; Mwatha J K; Sacko M; Vennervald B J; Dunne D W

来源：Parasite Immunology, 2013, 35(7-8): 224-228.

DOI：10.1111/pim.12035

• eosinophils
• helminth
• human
• IL-13
• IL-33
• schistosomiasis
• ST2

IL-33, a proposed alarmin, stimulates innate immune cells and Th2 cells to produce IL-13 and is rapidly upregulated upon antigen exposure in murine helminth infection. The human IL-33 response to helminth antigen was analysed in Malians infected with Schistosoma haematobium by disrupting parasite integrity via chemotherapy. Plasma IL-33 was measured pretreatment, and 24 h and 9 weeks post-treatment. At 24 h post-treatment, IL-33 levels were low. Nine week post-treatment IL-33 levels were elevated and were associated with an increase in intracellular IL-13 in eosinophils. Up-regulation of intracellular IL-13 in eosinophils was also associated with eosinophil expression of ST2L, the IL-33 receptor. IL-33 may play an important downstream role in the human response to schistosome adult worm antigen exposure.

• 出版日期2013-7