New methods for the synthesis of naphthyl amines; application to the synthesis of dihydrosanguinarine, sanguinarine, oxysanguinarine and (+/-)- maclekarpines B and C

作者：Tatton Matthew R; Simpson Iain; Donohoe Timothy J^*

来源：Chemical communications, 2014, 50(77): 11314-11316.

DOI：10.1039/c4cc05209a

A new method for preparing naphthyl amines from 1,5 unsaturated dicarbonyl precursors is described; the utility of this new method was proven in the syntheses of several natural products, all containing the benzo[c]phenanthridine core and enabled by a radical promoted cyclisation of the naphthyl amine products formed in the key cyclisation.

• 出版日期2014