Acceleromyographic monitoring of neuromuscular block over the orbicularis orris muscle in anesthetized patients receiving vecuronium

作者：Saitoh Yuhji^*; Oshima Tsutomu; Nakata Yoshinori

来源：Journal of Clinical Anesthesia, 2010, 22(5): 318-323.

DOI：10.1016/j.jclinane.2010.09.004

• Acceleromyography
• Monitoring
• Train-of-four
• Orbicularis oris muscle
• Vecuromum

Study Objective: To evaluate the level of neuromuscular block acceleromyographically over the orbicularis oris muscle
Design: Prospective, randomized, controlled study
Setting: Operating room of a university-affiliated hospital.
Patients: 36 adult, ASA physical status I and II women scheduled for mastectomy with air-oxygen-isoflurane-fentanyl anesthesia
Interventions: Patients were randomized to two groups In the orbicularis oris group (n=18). the facial nerve was stimulated and movement of the orbicularis oils muscle was measured acceleromyographically In the control group (n=18). adduction of the thumb was quantified mechanically
Measurements: Onset and recovery of neuromuscular block caused by vecuronium 0 1 mg/kg were compared between the groups
Main Results: Time to onset of neuromuscular block in the orbicularis oris group was significantly shorter than in the control group (176 52 vs 220 34 sec. mean SI), P = 0 004) Times to return of the first, second, third, or fourth (TI, T2, T3, or T4) response of train-of four (TOE). and recovery of TI/control were comparable between the groups Train-of-four ratio (T4/TI) in the orbicularis oris group was significantly higher than in the control group 50 to 120 minutes after vecuronium administration (P < 0 05)
Conclusion: Depth of neuromuscular block can be assessed acceleromyographically, over the orbicularis oils muscle O

• 出版日期2010-8
• 单位中国医学科学院肿瘤医院