Artemether-Lumefantrine Exposure in HIV-Infected Nigerian Subjects on Nevirapine-Containing Antiretroviral Therapy

作者：Parikh Sunil^*; Fehintola Fatai; Huang Liusheng; Olson Alexander; Adedeji Waheed A; Darin Kristin M; Morse Gene D; Murphy Robert L; Taiwo Babafemi O; Akinyinka Olusegun O; Adewole Isaac F; Aweeka Francesca T; Scarsi Kimberly K

来源：Antimicrobial Agents and Chemotherapy, 2015, 59(12): 7852-7856.

DOI：10.1128/AAC.01153-15

Coadministration of nevirapine-based antiretroviral therapy (ART) and artemether-lumefantrine is reported to result in variable changes in lumefantrine exposure. We conducted an intensive pharmacokinetic study with 11 HIV-infected adults who were receiving artemether-lumefantrine plus nevirapine-based ART, and we compared the results with those for 16 HIV-negative adult historical controls. Exposure to artemether and lumefantrine was significantly lower and dihydroartemisinin exposure was unchanged in subjects receiving nevirapine-based ART, compared with controls. Nevirapine exposure was unchanged before and after artemether-lumefantrine administration.

• 出版日期2015-12
• 单位西北大学