Mechanisms of disease - When cilia go bad: cilia defects and ciliopathies

作者:Fliegauf Manfred; Benzing Thomas; Omran Heymut*
来源:Nature Reviews Molecular Cell Biology, 2007, 8(11): 880-893.
DOI:10.1038/nrm2278

摘要

Defects in the function of cellular organelles such as peroxisomes, lysosomes and mitochondria are well-known causes of human diseases. Recently, another organelle has also been added to this list. Cilia-tiny hair-like organelles attached to the cell surface-are located on almost all polarized cell types of the human body and have been adapted as versatile tools forvarious cellular functions, explaining why cilia-related disorders can affect many organ systems. Several molecular mechanisms involved in cilia-related disorders have been identified that affect the structure and function of distinct cilia types.

  • 出版日期2007-11