A facile synthesis of the oxazolidinone antibacterial agent linezolid

作者：Li Yan Wu; Liu Yan; Jia Yun Can; Yuan Jian Yong^*

来源：Chinese Chemical Letters, 2013, 24(3): 230-232.

DOI：10.1016/j.cclet.2013.01.039

• Linezolid
• Synthesis
• Goldberg coupling reaction

A facile synthetic route of linezolid 1 has been developed. Using commercially available (R)-epichlorohydrin as the starting material, 1 was obtained through a sequence of cyclization, substitution, a Goldberg coupling, aminolysis and acetylation reactions. The synthetic route is easy to perform and can be scaled up.

• 出版日期2013-3
• 单位重庆医科大学