Melatonin utility in neonates and children

作者：Chen Yu Chieh; Tain You Lin; Sheen Jiunn Ming; Huang Li Tung^*

来源：Journal of the Formosan Medical Association, 2012, 111(2): 57-66.

DOI：10.1016/j.jfma.2011.11.024

• antioxidant
• children
• melatonin
• neonates
• sleep disorders

Melatonin (N-acetyl-5-methoxytryptamine) is an endogenously produced indoleamine secreted by the pineal gland and the secretion is suppressed by light. Melatonin is a highly effective antioxidant, free radical scavenger, and has anti-inflammatory effect. Plenty of evidence supports the utility of melatonin in adults for cancer, neurodegenerative disorders, and aging. In children and neonates, melatonin has been used widely, including for respiratory distress syndrome, bronchopulmonary dysplasia, periventricular leukomalacia (PVL), hypoxia ischemia encephalopathy and sepsis. In addition, melatonin can be used in childhood sleep and seizure disorders, and in neonates and children receiving surgery. This review article discusses the utility of melatonin in neonates and children.

• 出版日期2012-2
• 单位长春大学