A copper-catalyzed arylation of tryptamines for the direct synthesis of aryl pyrroloindolines

作者:Kieffer Madeleine E; Chuang Kangway V; Reisman Sarah E*
来源:Chemical Science, 2012, 3(11): 3170-3174.
DOI:10.1039/c2sc20914d

摘要

An operationally simple, copper-catalyzed arylation of N-tosyltryptamines provides direct access to C3-aryl pyrroloindolines. A range of electron-donating and electron-withdrawing substituents is tolerated on both the indole backbone and the aryl electrophile. These reactions occur under ambient temperatures and with equimolar quantities of the coupling partners.

  • 出版日期2012-11