Neural progenitor cells regulate microglia functions and activity

作者：Mosher Kira I; Andres Robert H; Fukuhara Takeshi; Bieri Gregor; Hasegawa Moriyama Maiko; He Yingbo; Guzman Raphael; Wyss Coray Tony^*

来源：Nature Neuroscience, 2012, 15(11): 1485-1487.

DOI：10.1038/nn.3233

We found mouse neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cells and to modulate microglial activation, proliferation and phagocytosis. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Thus, neural precursor cells may not only be shaped by microglia, but also regulate microglia functions and activity.

• 出版日期2012-11