Applications of surface-enhanced Raman scattering in advanced bio-medical technologies and diagnostics

作者:Nima Zeid A; Biswas Abhijit*; Bayer Ilker S; Hardcastle Franklin D; Perry Donald; Ghosh Anindya; Dervishi Enkeleda; Biris Alexandru S
来源:Drug Metabolism Reviews, 2014, 46(2): 155-175.
DOI:10.3109/03602532.2013.873451

摘要

In this review of the literature on surface-enhanced Raman scattering (SERS), we describe recent developments of this technique in the medical field. SERS has developed rapidly in the last few years as a result of the fascinating advancements in instrumentation and the ability to interpret complex Raman data using high-processional, computer-aided programs. This technique, has many advantages over ordinary spectroscopic analytical techniques - such as extremely high sensitivity, molecular selectivity, intense signal and great precision - that can be leveraged to address complex medical diagnostics problems. This review focuses on the SERS-active substrate, as well as major advances in cancer and bacteria detection and imaging. Finally, we present a perspective on anticipated future advancements in SERS techniques to address some of the most critical challenges in the areas of diagnostics, detection, and sensing.

  • 出版日期2014-5