Antihyperglycemic and Antihyperlipidemic Effects of Hesperidin and Naringin in High Fat Diet/Streptozotocin Type 2 Diabetic Rats

作者：Ahmed Osama Mohamed; Mahmoud Ayman Moawad^*; Abdel Moneim Adel; Ashour Mohamed B

来源：Life Science Journal-Acta Zhengzhou University Overseas Edition, 2011, 8(4): 91-101.

• Hesperidin
• naringin
• insulin resistance
• adiponectin
• resistin

The purpose of this study was to investigate the effect of hesperidin and naringin on blood glucose, glycosylated hemoglobin and serum insulin levels in high fat fed/streptozotocin-induced type 2 diabetic rats. Also this study evaluated effects of the tested compounds on lipid profile, serum adiponectin and resistin levels, serum cardiac function parameters and liver and muscle glycogen contents. An oral dose of 50 mg/kg b.wt. hesperidin or naringin was given continually for 30 days after diabetes induction. In the diabetic control group, levels of glucose, glycosylated hemoglobin, AST, LDH and CK-MB were significantly increased, while serum insulin level and hepatic and muscle glycogen were decreased. Both hesperidin and naringin supplementation significantly reversed these parameters. In addition, both compounds were found to alleviate lipid profile and serum adiponectin and resistin levels. These results showed that hesperidin and naringin have potential antihyperglycemic and antidyslipidemic activities in high fat fed/STZ-induced type 2 diabetic rats. [Osama Mohamed Ahmed; Ayman Moawad Mahmoud; Adel Abdel-Moneim and Mohamed B. Ashour Antihyperglycemic and Antihyperlipidemic Effects of Hesperidin and Naringin in High Fat Diet/Streptozotocin Type 2 Diabetic Rats] Life Science Journal. 2011; 8(4): 91-101] ISSN: 1097-8135). http://www.lifesciencesite.com.

• 出版日期2011