Association between FTO gene polymorphisms and type 2 diabetes mellitus, serum levels of apelin and androgen hormones among Iranian obese women

作者：Ghafarian Alipour Farzaneh; Ziaee Shayan; Ashoori Mohamad Reza; Zakeri Mir Saeid; Borournand Mohammad Ali; Aghamohammadzadeh Naser; Abbasi Majdi Maryam; Shool Fatemeh; A**aghi Navid Sarakhs; Mohammadi Abolghasem; Zarghami Nosratollah

来源：Gene, 2018, 641: 361-366.

DOI：10.1016/j.gene.2017.10.082

• FTO gene
• Polymorphism
• Obesity
• Type 2 diabetes mellitus
• Apelin

Background and aims: Recent studies show that FTO single nucleotide polymorphisms (SNPs) are associated with obesity and type 2 diabetes mellitus (T2DM). On the other hand, many animal models and clinical studies have demonstrated that apelin, an adipocytokine, is related to the obesity and T2DM. Additionally, obese women are at risk of Hyperandrogenemia. So, the aim of this study was to investigate the relationship between FTO variants (rs763967273, rs759031579, rs141115189, rs9926289, rs76804286 and rs9939609) with T2DM, serum apelin and androgenic hormones in Iranian obese women.
Subjects and methods: 197 obese women (123 women with T2DM and 74 women as healthy control) were participated in this study. Anthropometrical and biochemical characteristics were measured. Serum apelin and androgen hormones levels were determined in 66 subjects consisting of 33 cases and 33 controls. PCR were carried out and subsequently, the PCR production was genotyped by Sanger sequencing assay.
Results: Our observations showed that all SNPs are related to T2DM. The rs9926289 FTO variant had a strong association with serum apelin and dehydroepiandrosterone-sulfate levels (P = 0.04 and P = 0.03, respectively) among SNPs. In addition, apelin and androgenic hormones were correlated with T2DM. Two polymorphisms including rs9939609 and rs9926289 had a strong Linkage disequilibrium (r(2) = 1).
Conclusion: FTO variants not only were associated with T2DM, but also some variants had a strong association with apelin and androgenic hormones profile.

• 出版日期2018-1-30