Activity of Matrix Metalloproteinases during Antimycobacterial Therapy in Mice with Simulated Tuberculous Inflammation

作者：Sumenkova D V^*; Russkikh G S; Poteryaeva O N; Polyakov L M; Panin L E

来源：Bulletin of Experimental Biology and Medicine, 2013, 155(1): 34-36.

DOI：10.1007/s10517-013-2073-9

• matrix metalloproteinases (MMP-2, MMP-7)
• isoniazid
• tuberculosis

Matrix metalloproteinases are shown to be involved in the pathogenesis of tuberculosis inflammation. In the early stages of BCG-granuloma formation in mouse liver and lungs, the serum levels of matrix metalloproteinases 2 and 7 increased by 4.5 times and remained unchanged while the pathology developed. Antimycobacterial therapy with isoniazid reduced enzyme activity almost to the level of intact control. The decrease in activity of matrix metalloproteinases 2 and 7 that play the most prominent role in the development of destructive forms of tuberculosis is of great therapeutic importance.

• 出版日期2013-5