Clinical characteristics of Japanese patients with severe hypertriglyceridemia

作者：Tada Hayato^*; Kawashiri Masa aki; Nakahashi Takuya; Yagi Kunimasa; Chujo Daisuke; Ohbatake Azusa; Mori Yukiko; Mori Shunsuke; Kometani Mitsuhiro; Fujii Hiroshi; Nohara Atsushi; Inazu Akihiro; Mabuchi Hiroshi; Yamagishi Masakazu; Hayashi Kenshi

来源：Journal of Clinical Lipidology, 2015, 9(4): 519-524.

DOI：10.1016/j.jacl.2015.05.004

• Triglyceride
• Lipoprotein
• Coronary artery disease
• Pancreatitis
• Hypertriglyceridemia

BACKGROUND: Although of interest, few data exist on the clinical characteristics of Japanese patients with an extremely high triglyceride level (>= 1000 mg/dL).
OBJECTIVE: We assessed the clinical characteristics of Japanese patients with an extremely high triglyceride level.
METHODS: We investigated the presence of coronary artery disease, history of pancreatitis, the presence of fatty liver, and the potential causes of elevated triglyceride in Japanese subjects with an extremely high level of fasting triglyceride (>= 1000 mg/dL) among 70,368 subjects whose serum triglyceride was measured for any reason at Kanazawa University Hospital from April 2004 to March 2014.
RESULTS: We identified 215 (0.31%) subjects (mean age, 46 years; male, 170, mean body mass index, 25 kg/m(2)) with severe hypertriglyceridemia. Among them, 4 (1.9%) subjects were classified as type I, 97 (45.1%) subjects were type IV, and 114 (53.0%) subjects were type V hyperlipidemia, according to Fredrickson's classification. Among 215 subjects, 116 subjects (54.0%) drank alcohol, 58 (27.0%) showed heavy intake (>= 60 g/d), and 64 (29.8%) subjects had diabetes. In total, 59 (27.4%) subjects had transient severe hypertriglyceriderhia caused by corticosteroids (N = 19), antidepressant (N = 18), L-asparaginase and steroids for acute lymphoid leukemia (N = 15), hormone replacement therapy for breast cancer (N = 9), O-blocker (N = 5), hypothyroidism (N = 4), pregnancy (N = 4), and panhypopituitarism (N = 2). As many as 119 (55.3%) subjects exhibited fatty liver. Moreover, 12 (5.6%) and 17 (7.9%) subjects had a history of pancreatitis and coronary artery disease, respectively.

• 出版日期2015-8