BrainEXP: a database featuring with spatiotemporal expression variations and co-expression organizations in human brains

作者：Jiao, Chuan; Yan, Pengpeng; Xia, Cuihua; Shen, Zhaoming; Tan, Zexi; Tan, Yanyan; Wang, Kangli; Jiang, Yi; Huang, Lingling; Dai, Rujia; Wei, Yu; Xia, Yan; Meng, Qingtuan; Ouyang, Yanmei; Yi, Liu; Duan, Fangyuan; Dai, Jiacheng; Zhao, Shunan; Liu, Chunyu^*; Chen, Chao^*

来源：Bioinformatics, 2019, 35(1): 172-174.

DOI：10.1093/bioinformatics/bty576

• TRANSCRIPTOME

Gene expression changes over the lifespan and varies among different tissues or cell types. Gene co-expression also changes by sex, age, different tissues or cell types. However, gene expression under the normal state and gene co-expression in the human brain has not been fully defined and quantified. Here we present a database named Brain EXPression Database (BrainEXP) which provides spatiotemporal expression of individual genes and co-expression in normal human brains. BrainEXP consists of 4567 samples from 2863 healthy individuals gathered from existing public databases and our own data, in either microarray or RNA-Seq library types. We mainly provide two analysis results based on the large dataset: (i) basic gene expression across specific brain regions, age ranges and sexes; (ii)co-expression analysis from different platforms.

• 出版日期2019-1-1
• 单位中南大学