An optimal allocation for response-adaptive designs

作者：Yi Yanqing^*; Yuan Yuan

来源：Journal of Applied Statistics, 2013, 40(9): 1996-2008.

DOI：10.1080/02664763.2013.800846

• optimal allocation
• response-adaptive design
• Neyman allocation
• balanced allocation
• ethical advantage
• statistical power

A new allocation proportion is derived by using differential equation methods for response-adaptive designs. This new allocation is compared with the balanced and the Neyman allocations and the optimal allocation proposed by Rosenberger, Stallard, Ivanova, Harper and Ricks (RSIHR) from an ethical point of view and statistical power performance. The new allocation has the ethical advantages of allocating more than 50% of patients to the better treatment. It also allocates higher proportion of patients to the better treatment than the RSIHR optimal allocation for success probabilities larger than 0.5. The statistical power under the proposed allocation is compared with these under the balanced, the Neyman and Rosenberger's optimal allocations through simulation. The simulation results indicate that the statistical power under the proposed allocation proportion is similar as to those under the balanced, the Neyman and the RSIHR allocations.

• 出版日期2013-9-1