MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells

作者：Saeland Eirikur^*; de Jong Marein A W P; Nabatov Alexey A; Kalay Hakan; Geijtenbeek Teunis B H; van Kooyk Yvette

来源：Molecular Immunology, 2009, 46(11-12): 2309-2316.

DOI：10.1016/j.molimm.2009.03.025

• Human milk
• Human immunodeficiency virus
• Dendritic cells
• MUC1
• Glycosylation

Mother-to-child transmission of human immunodeficiency virus-1 (HIV-1) occurs frequently via breast-feeding. HIV-1 targets DC-SIGN+ dendritic cells (DCs) in mucosal areas that allow efficient transmission of the virus to T cells. Here, we demonstrate that the epithelial mucin MUC1, abundant in milk, efficiently bound to DC-SIGN on DC. The O-linked glycans within the mucin domain contained Lewis X structures, that were specifically recognized by the receptor. Interestingly, MUC1 prevented DC-SIGN-mediated transmission of HIV-1 from DCs to CD4+ T cells. We hypothesize that repetitive units of Lewis X, within the mucin domain, play an important role in inhibiting transmission of HIV-1 from mother to child.

• 出版日期2009-7