A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

作者：Salmena Leonardo; Poliseno Laura; Tay Yvonne; Kats Lev; Pandolfi Pier Paolo^*

来源：Cell, 2011, 146(3): 353-358.

DOI：10.1016/j.cell.2011.07.014

Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.

• 出版日期2011-8-5