A cascade reaction for the new and direct synthesis of indolofuroquinoxalines

作者：Nikumbh Satish P; Raghunadh Akula; Rao T Srinivasa; Murthy V Narayana; Joseph Suju C; Murthy Y L N; Pal Manojit^*

来源：RSC Advances, 2016, 6(28): 23489-23497.

DOI：10.1039/c6ra03556f

The 7H-indolo[3',2':4,5]furo[2,3-b]quinoxaline derivatives are synthesized directly from methyl 2-(2-chloro-1H-indol-3-yl)-2-oxoacetate or its N-alkyl derivatives under neutral or mildly acidic conditions. This new one-pot methodology was found to be general and greener as it avoids the use of environmentally harmful POCl3 and strong alkali required for the previously reported method. It is also amenable for scale-up.

• 出版日期2016