A Case of Atypical Adult-onset Tic Disorder

作者：Colosimo Carlo^*

来源：Neurologist, 2015, 19(4): 99-100.

DOI：10.1097/NRL.0000000000000023

• basal ganglia
• Huntington disease
• neurodegenerative diseases
• tics

Introduction: The differential diagnosis of adult tic disorder is complex, and several common and uncommon causes have to be taken into consideration.
Case Report: A 30-year-old man came to our movement disorders clinic with multiple tics which had begun insidiously about 10 years earlier. No family history was reported, but his 65-year-old otherwise healthy father also had very subtle involuntary movements. A diagnosis of atypical Gilles de la Tourette syndrome was made. However, the neurological and psychiatric symptoms of the patient rapidly progressed over the following 2 years, resulting in increasingly severe involuntary movements and profound mood disorder. Further diagnostic tests were performed, and a genetic screening for Huntington disease revealed 45 repeats of the CAG nucleotide in the IT-15 gene.
Conclusion: This case underlines the marked phenotypic variability of Huntington disease at presentation, including the presence of involuntary movements different from chorea and possibility of an apparently sporadic disorder.

• 出版日期2015-4