New phenylpyridone derivatives from the Penicillium sumatrense GZWMJZ-313, a fungal endophyte of Garcinia multiflora

作者：Xu, Yanchao; Wang, Liping; Zhu, Guoliang; Zuo, Mingxing; Gong, Qianyu; He, Wenwen; Li, Mingpeng; Yuan, Chunmao; Hao, Xiaojiang^*; Zhu, Weiming^*

来源：Chinese Chemical Letters, 2019, 30(2): 431-434.

DOI：10.1016/j.cclet.2018.08.015

• Penicillium sumatrense
• Garcinia multiflora
• Pyridones
• Antibacterial activities
• Endophytic fungi

Citridones E-G (1-3), three new phenylpyridone derivatives together with two known curvularins (4 and 5) were isolated from the solid culture of the endophytic fungus Penicillium sumatrense GZWMJZ-313 in Garcinia multiflora. The structures of new compounds were determined in the light of spectroscopic data, X-ray and ECD calculation. Compounds 1 and 3 are racemates, while compound 2 is optically pure. Compounds 1 and 4 showed antibacterial and antifungal activities against Staphylococcus aureus, Pseudomonas aeruginosa, Clostridium perfringens, Escherichia coli and Candida albicans with MIC values ranging from 8 mu g/mL to 64 mu g/mL.

• 出版日期2019-2
• 单位贵州省中国科学院天然产物化学重点实验室; 中国海洋大学