Are ultrasound renal aspects associated with urinary biochemistry in fetuses with lower urinary tract obstruction

作者：Nassr Ahmed A; Koh Chester Koh; Shamshirsaz Alireza A; Espinoza Jimmy; Sangi Haghpeykar Haleh; Sharhan Dina; Welty Stephen; Angelo Joseph; Roth David; Belfort Michael A; Braun Michael; Ruano Rodrigo

来源：Prenatal Diagnosis, 2016, 36(13): 1206-1210.

DOI：10.1002/pd.4958

Objective To evaluate the association between ultrasonographic renal parameters and urine biochemistry in fetuses with lower urinary tract obstruction (LUTO).
Methods Data were collected prospectively from 31 consecutive fetuses with LUTO that underwent vesicocentesis for fetal urinary biochemistry between April 2013 and September 2015. The following renal ultrasound markers were assessed immediately before the vesicocentesis: renal echogenicity, presence of cortical cysts, presence of findings suggestive of 'renal dysplasia' (hyperechogenic cystic kidneys with no cortical-medullary differentiation) and severe oligohydramnios (amniotic fluid< 5th percentile). The association of these parameters to the fetal urinary concentration of sodium, chloride, calcium, osmolality and beta2-microglobulin was investigated by logistic regression analysis.
Results There was no relationship between any of the ultrasonographic fetal renal characteristics and fetal urinary biochemistry.
Conclusions In LUTO, the ultrasound appearance of the fetal kidneys and urinary biochemistry are not correlated. It may be better to take both ultrasound and biochemistry into account when evaluating fetuses with fetal LUTO.

• 出版日期2016-12