Alpha-tocopherol and alpha-lipoic acid. An antioxidant synergy with potential for preventive medicine

作者：Gonzalez Perez Oscar^*; Angelica Moy Lopez Norma; Guzman Muniz Jorge

来源：Revista de Investigacion Clinica, 2008, 60(1): 58-67.

• thioctic acid
• vitamin E
• antioxidants
• vitamins
• reactive oxygen species

Reactive oxygen species (ROS) have been involved in the induction and progression of damage of many human disorders, such as: heart infarction, cerebral ischemia, diabetic neuropathy, Alzheimer's disease, etc. In several studies, the synergism between alpha-lipoic acid and vitamin E has been described and potent antioxidant effects can be obtained when both antioxidants are simultaneously used. This review highlights recent findings showing that the combination of alpha-lipoic acid plus vitamin E effectively reduces oxidative damage in brain and cardiac ischemia as well as in other pathological events related to ROS increasing. These antioxidants are present in a broad variety of foods, are also available in several dietary supplements and their side effects are very rare. Therefore, alpha-lipoic acid and vitamin E may play an important role in clinical preventive medicine and human nutrition.

• 出版日期2008-2