Decreased expression of follicular dendritic cell-secreted protein correlates with increased immunoglobulin A production in the tonsils of individuals with immunoglobulin A nephropathy

作者：Meng, Hong-Xue^*; Li, Hui-Ning; Geng, Jia-Shi; Ohe, Rintaro; Yu, Xiao-Yu; E, Xiao-Qiang; Ye, Fei; Yang, Su-Ran; Kato, Tomoya; Zhang, Lei; Ishida, Akihiro; Ohta, Nobuo; Jin, Xiao-Ming; Kakehata, Seiji; Geng, Jing-Shu; Yamakawa, Mitsunori

来源：Translational Research, 2015, 166(3): 281-291.

DOI：10.1016/j.trsl.2015.04.004

• IGA NEPHROPATHY
• FDC-SP
• OXFORD CLASSIFICATION
• B-CELLS
• TONSILLECTOMY
• PROGRESSION
• DEPOSITION

Immunoglobulin A nephropathy (IgAN) is characterized by a qualitative abnormality of IgA in the circulation and IgA deposition in the renal mesangium. Recent research has indicated that pathogenic IgA may originate from affected tonsils. Follicular dendritic cell-secreted protein (FDC-SP), a small novel secretory protein that may regulate the induction of B-cell responses, has been suggested to control IgA production. Given this background, this study investigated the expression of FDC-SP and its correlation with IgA production in the tonsils of IgAN patients. lmmunohisto-chemistry and reverse transcription-polymerase chain reaction were used to compare the expression of FDC-SP in the tonsils of IgAN patients with tonsillitis and of non-IgAN patients with chronic tonsillitis. The location of FDC-SP in tonsillar tissue was confirmed by double immunofluorescence. We found that FDC-SP expression significantly decreased and was correlated negatively with enhanced IgA production in the tonsils of IgAN patients. FDC-SP secreted by follicular dendritic cells may act on germinal center B cells and participate in the modulation of IgA generation in the tonsils. Our study demonstrated that FDC-SP may be involved in IgA production in the tonsils of IgAN patients, making this protein an attractive candidate immunomodulator, and highlighting a promising strategy for therapeutic intervention in IgAN.

• 出版日期2015-9
• 单位哈尔滨医科大学